After the 2022 JLT Community Series (pre-season), the AFL premiership regular season will be the 126th season of the elite Australian rules football competition. The first round game is scheduled to start on Wednesday, March 16, 2022.
AFL 2022 Schedule for Regular Season Round 1:
| DATE | EVENT | VENUE | TIME |
| March, 16 Wednesday | Melbourne vs. Western Bulldogs | MCG | 7.10pm (Seven) |
| March, 17 Thursday | Carlton vs. Richmond | MCG | 7.25pm (Seven) |
| March, 18 Friday | St Kilda vs. Collingwood | Marvel Stadium | 7.50pm (Seven) |
| March, 19 Saturday | Geelong vs. Essendon | MCG | 2.10pm (Fox) |
| March, 19 Saturday | GWS vs. Sydney | Accor Stadium | 5.10pm (Fox) |
| March, 19 Saturday | Brisbane vs. Port Adelaide | Gabba | 8.10pm (Seven) |
| March, 20 Sunday | Hawthorn vs. North Melbourne | MCG | 1.10pm (Fox) |
| March, 20 Sunday | Adelaide vs. Fremantle | Adelaide Oval | 4.10pm (Fox) |
| March, 20 Sunday | West Coast vs. Gold Coast | Optus Stadium | 7.40pm (Fox) |
AFL 2022 Regular Season Round 1 Ends on Sunday, March 20 and then it goes to AFL Regular Season Round 2.