AFL Footy Games Regular Season round 4 starts on Thursday, April 7, 2022.
AFL 2022 Regular Season round 4 at glance:
| DATE | EVENT | VENUE | TIME |
| 7, April Thursday | Port Adelaide vs. Melbourne | Adelaide Oval | 7.40pm (Seven) |
| 8, April Friday | Geelong Cats vs. Brisbane Lions | GMHBA Stadium | 7.50pm (Seven) |
| 9, April Saturday | Sydney Swans vs. North Melbourne | SCG | 1.45pm (Fox) |
| 9, April Saturday | Collingwood vs. West Coast Eagles | Marvel Stadium | 4.35pm (Fox) |
| 9, April Saturday | Richmond vs. Western Bulldogs | MCG | 7.25pm (Seven) |
| 9, April Saturday | Fremantle vs. GWS Giants | Optus Stadium | 7.25pm (Fox) |
| 10, April Sunday | Essendon vs. Adelaide Crows | Marvel Stadium | 1.10pm (Fox) |
| 10, April Sunday | Hawthorn vs. St Kilda | MCG | 3.20pm (Seven) |
| 10, April Sunday | Gold Coast Suns vs. Carlton | Metricon Stadium | 4.10pm (Fox) |
Round 4 Game Ends on Sunday, April 10, 2022