AFL Footy Games Regular Season round 5 starts on Thursday, April 14, 2022.
AFL 2022 Regular Season round 5 at glance:
| DATE | EVENT | VENUE | TIME |
| 14, April Thursday | Brisbane Lions vs. Collingwood | The Gabba | 7.35pm (Seven) |
| 15, April Friday | North Melbourne vs. Western Bulldogs | Marvel Stadium | 4.20pm (Seven) |
| 15, April Friday | West Coast Eagles vs. Sydney Swans | Optus Stadium | 7.40pm (Fox) |
| 16, April Saturday | St Kilda vs. Gold Coast Suns | Marvel Stadium | 1.45pm (Fox) |
| 16, April Saturday | Adelaide Crows vs. Richmond | Adelaide Oval | 4.35pm (Fox) |
| 16, April Saturday | Melbourne vs. GWS Giants | MCG | 7.25pm (Seven) |
| 17, April Sunday | Carlton vs. Port Adelaide | MCG | 1.40pm (Fox) |
| 17, April Sunday | Essendon vs. Fremantle | Marvel Stadium | 4.40pm (Fox) |
| 14, April Monday | Hawthorn vs. Geelong Cats | MCG | 3.20pm (Seven) |
Round 5 Game Ends on Monday, April 18, 2022.