AFL Footy Games Regular Season round 6 starts on Friday, April 22, 2022.
AFL 2022 Regular Season round 6 at glance:
| DATE | EVENT | VENUE | TIME |
| 22, April Friday | GWS Giants vs. St Kilda | Manuka Oval | 7.50pm (Seven) |
| 23, April Saturday | Western Bulldogs vs. Adelaide Crows | Mars Stadium | 1.45pm (Fox) |
| 23, April Saturday | Port Adelaide vs. West Coast Eagles | Adelaide Oval | 4.35pm (Fox) |
| 23, April Saturday | Fremantle vs. Carlton | Optus Stadium | 7.40pm (Seven) |
| 24, April Sunday | North Melbourne vs. Geelong Cats | Blundstone Arena | 1.10pm (Fox) |
| 24, April Sunday | Gold Coast Suns vs. Brisbane Lions | Metricon Stadium | 4.10pm (Fox) |
| 24, April Sunday | Richmond vs. Melbourne | MCG | 7.25pm (Seven) |
| 25, April Monday | Hawthorn vs. Sydney Swans | University of Tasmania Stadium | 12.30pm (Fox) |
| 25, April Monday | Essendon vs. Collingwood | MCG | 3.20pm (Seven) |
Round 6 Game Ends on Sunday, April 25, 2022.